A blog for Gannet, a batch-analysis tool for GABA-edited MRS data
Wednesday 16 January 2013
Field Drift and fMRI
Some scanners suffer from rather large field drifts after fMRI acquisitions, due to heating of passive shims and other metal in the scanner. We are working on the extent to which this impacts measurements. Dr Benjamin Glaubitz in Bochum acquired this data showing the dramatic field drift caused by a single 10-minute fMRI run. Gannet seems to do a reasonable job of correcting the drift (although whether it removes all the effects of the drift is not yet clear).
Clearly there are some studies which require fMRI to be performed before GABA-MRS< but if you can avoid it, we'd suggest leaving fMRI (or DTI) until after the GABA scans.
A GABA paper review of 2012
Mainly to stop the promise of Gannet 2.0 from haunting me in the most recent post, I thought I'd do a quick look-back over 2012. Some of this is shameless plugging, some is poorly focused musings... either way, here is a quick review with links to some of our (and other people's) GABA MRS papers from 2012).
December 2012
For me, the highlight was the acceptance of our "Current Pracice in GABA MRS" review paper that came out of the 2011 Cardiff Symposium. Paul Mullins did a great job of keeping it moving and it should be out in the new year in a special edition on GABA MRS.
November 2012
Dikoma Shungu's groups published a few GABA papers this year, this paper in OCD and also two AGP papers (!) earlier in the year in Schizophrenia and Depression.
September 2012
Charlie Stagg in Oxford has done some great work manipulating the GABA system with TMS and tDCS, and here she asks the million-dollar question "What are we measuring with GABA MRS?". A very interesting question and paper.
August 2012
Linking in great with the "What are we measuring?" question are a few genetic studies that relate brain, or in this case CSF, GABA to genetic variants.
July 2012
It was great to see a couple of long-term collaborations come to fruit in July, with James Stone publishing his Ketamine challenge study in Molecular Psychiatry, and my ADHD collaboration with Stewart Mostofsky in AGP.
June 2012
The role of GABA in sleep is an interesting area and a few groups have started to look at Insomnia.
May 2012
Speaking of collaborations baring fruit, Brad Foerster and the UMichigan group have published a pilot in ALS, with a follow-up of a larger cohort in press at JAMA Neurology.
Feb 2012
Graeme Mason's group showed that ethanol decreases brain GABA, maybe a counter-intuitive result, but one that fits with a 'more GABA, better performance' trend in individual difference studies.
Jan 2012
While doing reading for a grant submission in 2010, I let myself get waylaid by writing a review of the same material. This kicked off a productive (in papers terms) 2012 for us, and a second paper for my postdoc Nick Puts. The first paper also came out that applied GABA MRS to Parkinson's Disease - an area where the technique is very relevant, if only we can get things to work well subcortically.
If your paper isn't up here, I probably missed it - no slight intended!
December 2012
For me, the highlight was the acceptance of our "Current Pracice in GABA MRS" review paper that came out of the 2011 Cardiff Symposium. Paul Mullins did a great job of keeping it moving and it should be out in the new year in a special edition on GABA MRS.
November 2012
Dikoma Shungu's groups published a few GABA papers this year, this paper in OCD and also two AGP papers (!) earlier in the year in Schizophrenia and Depression.
Charlie Stagg in Oxford has done some great work manipulating the GABA system with TMS and tDCS, and here she asks the million-dollar question "What are we measuring with GABA MRS?". A very interesting question and paper.
August 2012
Linking in great with the "What are we measuring?" question are a few genetic studies that relate brain, or in this case CSF, GABA to genetic variants.
July 2012
It was great to see a couple of long-term collaborations come to fruit in July, with James Stone publishing his Ketamine challenge study in Molecular Psychiatry, and my ADHD collaboration with Stewart Mostofsky in AGP.
June 2012
The role of GABA in sleep is an interesting area and a few groups have started to look at Insomnia.
May 2012
Speaking of collaborations baring fruit, Brad Foerster and the UMichigan group have published a pilot in ALS, with a follow-up of a larger cohort in press at JAMA Neurology.
Feb 2012
Graeme Mason's group showed that ethanol decreases brain GABA, maybe a counter-intuitive result, but one that fits with a 'more GABA, better performance' trend in individual difference studies.
Jan 2012
While doing reading for a grant submission in 2010, I let myself get waylaid by writing a review of the same material. This kicked off a productive (in papers terms) 2012 for us, and a second paper for my postdoc Nick Puts. The first paper also came out that applied GABA MRS to Parkinson's Disease - an area where the technique is very relevant, if only we can get things to work well subcortically.
If your paper isn't up here, I probably missed it - no slight intended!
Subscribe to:
Posts (Atom)